Short-term variation of HIV tropism readouts in the absence of CCR5 antagonists
نویسندگان
چکیده
Methods Population-based and “deep” V3-loop sequencing were performed in 53 MVC recipients in the MERIT, MOTIVATE and A4001029 studies who spontaneously changed tropism readout by the original Trofile assay between screening and baseline (~4-8 weeks) and 72 randomly sampled patients who did not change. Tropism was inferred by “geno2pheno” with previously defined cutoffs: 2% X4 prevalence with a 3.5% false-positive rate (fpr) for “deep” sequencing; 5.75% fpr for population-based sequencing.
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